Differences Between a Pseudoaneurysm and a True Aneurysm
True Aneurysm
A localized dilation of an artery involving all three layers of the vessel wall: intima, media, and adventitia.
Pseudoaneurysm (False Aneurysm)
A contained rupture of the arterial wall where blood leaks out and is held by surrounding tissues, not by the full vessel wall layers.
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Pathophysiology
True Aneurysm
Vessel wall weakens → gradual dilation
Wall structure remains intact
Common in chronic conditions
Pseudoaneurysm
Disruption of vessel wall → blood escapes
Forms a pulsatile hematoma communicating with artery
Wall is formed by fibrous tissue or surrounding structures
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Structural Difference
Feature True Aneurysm Pseudoaneurysm
Vessel wall layers All 3 layers intact Not intact
Wall composition Native arterial wall Surrounding tissue / thrombus
Neck Broad Narrow neck
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Common Causes
True Aneurysm
Atherosclerosis (most common)
Hypertension
Connective tissue disorders (e.g., Marfan syndrome)
Degenerative changes
Pseudoaneurysm
Trauma
Iatrogenic (post catheterization, procedures)
Infection
Surgical complications
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Common Sites
True Aneurysm
Abdominal aorta (AAA)
Thoracic aorta
Popliteal artery
Pseudoaneurysm
Femoral artery (post catheterization)
Radial artery
Anastomotic surgical sites
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Clinical Features
True Aneurysm
Often asymptomatic
May present as pulsatile mass
Risk of rupture if large
Pseudoaneurysm
Painful, tender swelling
Pulsatile mass with bruit
Rapid expansion more common
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Imaging Findings
True Aneurysm
Uniform dilation
Intact vessel wall
No “neck”
Pseudoaneurysm
“Yin-yang sign” on Doppler
Narrow neck connecting to artery
To-and-fro flow pattern
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Complications
True Aneurysm
Rupture
Thrombosis
Embolization
Pseudoaneurysm
Rupture (higher acute risk)
Compression of nearby structures
Infection
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Management
True Aneurysm
Surveillance if small
Surgical repair or EVAR if large or symptomatic
Pseudoaneurysm
Ultrasound-guided compression
Thrombin injection
Surgical repair if unstable
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Key Exam Pearls
True aneurysm = all vessel wall layers involved
Pseudoaneurysm = contained rupture with narrow neck
Yin-yang sign → classic for pseudoaneurysm
Post-procedure pulsatile swelling → think pseudoaneurysm
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One-Line Summary
True aneurysm is a dilated intact vessel, while pseudoaneurysm is a contained arterial rupture outside the vessel wall.

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