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Patient with AF and acute IS/TIA
European Heart Association Guideline recommends:
• 1 days after TIA
• 3 days after mild stroke
• 6 days after moderate stroke
• 12 days after severe stroke
Early anticoagulation can decrease a risk of recurrent stroke and embolic events but may increase a risk of secondary hemorrhagic transformation of brain infarcts.
The 1-3-6-12-day rule is a known consensus with graded increase in delay of anticoagulation between 1 and 12 days after onset of ischemic stroke or transient ischemic attack(TIA), according to neurological severity based on European expert opinions.
However, this rule might be somewhat later than currently used in a real-world practical setting.

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