Ankle–Brachial Pressure Index (ABPI)
Definition
Ankle–Brachial Pressure Index (ABPI), also called Ankle–Brachial Index (ABI), is a simple, non-invasive bedside test that compares systolic blood pressure at the ankle with systolic blood pressure at the brachial artery to assess lower-limb arterial perfusion.
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Principle
Peripheral arterial disease (PAD) causes reduced systolic pressure distal to arterial stenosis or occlusion. Comparing ankle pressure with arm pressure provides an objective estimate of arterial flow to the legs.
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Formula
ABPI =
Highest ankle systolic pressure (dorsalis pedis or posterior tibial) ÷ Highest brachial systolic pressure
Measured separately for each leg.
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Methods of Measuring ABPI
1. Doppler-Assisted ABPI (Gold Standard)
Equipment
Hand-held Doppler (8–10 MHz)
Sphygmomanometer cuffs (appropriate size)
Steps
1. Patient rests supine for ≥10 minutes
2. Measure systolic BP in both brachial arteries using Doppler
3. Measure systolic BP at:
Dorsalis pedis artery
Posterior tibial artery
4. Use the higher ankle pressure and higher brachial pressure for calculation
Advantages
Most accurate bedside method
Widely recommended in guidelines
Limitations
Requires operator skill
Time-consuming in busy clinics
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2. Automated Oscillometric ABPI
Description
Automated BP devices measure arm and ankle pressures simultaneously or sequentially
Advantages
Quick
Minimal training required
Limitations
Less accurate in:
Diabetes
Chronic kidney disease
Severe PAD
May underestimate disease severity
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3. Toe–Brachial Index (TBI) (When ABPI is Unreliable)
Indications
Non-compressible arteries (ABPI >1.3)
Diabetes mellitus
Medial arterial calcification
Normal TBI
≥0.7
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Interpretation of ABPI
ABPI Value Interpretation
1.00 – 1.30 Normal
0.91 – 0.99 Borderline
0.41 – 0.90 Mild–Moderate PAD
≤0.40 Severe PAD
>1.30 Non-compressible arteries
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Clinical Uses of ABPI
1. Diagnosis of Peripheral Arterial Disease
Detects symptomatic and asymptomatic PAD
Correlates with angiographic disease severity
2. Cardiovascular Risk Stratification
Low ABPI is an independent predictor of:
Myocardial infarction
Stroke
Cardiovascular mortality
3. Assessment of Leg Pain
Differentiates vascular claudication from:
Neurogenic claudication
Musculoskeletal pain
4. Wound and Ulcer Assessment
Guides safety of compression therapy in venous ulcers
Predicts wound healing potential
5. Pre- and Post-Revascularization Evaluation
Baseline assessment before intervention
Objective follow-up after angioplasty or surgery
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Contraindications / Cautions
Severe leg pain or acute limb ischemia (do not delay urgent care)
Incorrect cuff size can produce false results
Calcified arteries may falsely elevate ABPI
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Factors Affecting Accuracy
Diabetes mellitus
Chronic kidney disease
Advanced age
Edema
Improper patient positioning
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Key Points
ABPI is a rapid, inexpensive, and non-invasive test
Doppler-assisted method is preferred for accuracy
Abnormal ABPI indicates both limb ischemia and systemic atherosclerosis
High values (>1.3) are not normal and require alternative assessment
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