Bicuspid aortic valve with Severe AR

Bicuspid Aortic Valve (BAV) can cause severe aortic regurgitation (AR) through several mechanisms:

Congenital Abnormalities

1. Abnormal valve morphology: BAVs often have an abnormal valve morphology, which can lead to incomplete closure of the valve leaflets, resulting in AR.

2. Fusion of valve leaflets: In BAV, the valve leaflets may be fused together, creating a single, abnormal leaflet that cannot close properly, leading to AR.

Acquired Changes

1. Valve calcification: Over time, BAVs can become calcified, leading to stiffening of the valve leaflets and incomplete closure, resulting in AR.

2. Valve prolapse: BAVs can also prolapse, causing the valve leaflets to bulge backward into the left ventricle, leading to AR.

Aortic Root Changes

1. Aortic root dilation: BAVs are often associated with aortic root dilation, which can lead to AR by causing the valve leaflets to become misaligned.

2. Aortic aneurysm formation: In some cases, BAVs can lead

[3/4, 1:39 PM] Meta AI: Bicuspid Aortic Valve (BAV) can cause severe aortic regurgitation (AR) through several mechanisms:

Congenital Abnormalities

1. Abnormal valve morphology: BAVs often have an abnormal valve morphology, which can lead to incomplete closure of the valve leaflets, resulting in AR.

2. Fusion of valve leaflets: In BAV, the valve leaflets may be fused together, creating a single, abnormal leaflet that cannot close properly, leading to AR.

Acquired Changes

1. Valve calcification: Over time, BAVs can become calcified, leading to stiffening of the valve leaflets and incomplete closure, resulting in AR.

2. Valve prolapse: BAVs can also prolapse, causing the valve leaflets to bulge backward into the left ventricle, leading to AR.

Aortic Root Changes

1. Aortic root dilation: BAVs are often associated with aortic root dilation, which can lead to AR by causing the valve leaflets to become misaligned.

2. Aortic aneurysm formation: In some cases, BAVs can lead to the formation of an aortic aneurysm, which can cause AR by stretching the valve leaflets apart.

Other Factors

1. Genetic predisposition: Some individuals with BAV may have a genetic predisposition to develop AR.

2. Hemodynamic changes: Changes in blood flow and pressure can also contribute to the development of AR in individuals with BAV.

These mechanisms can contribute to the development of severe AR in individuals with BAV, highlighting the importance of regular monitoring and timely intervention.

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𝘼𝙣𝙩𝙞𝙘𝙤𝙖𝙜𝙪𝙡𝙖𝙩𝙞𝙤𝙣 𝘼𝙛𝙩𝙚𝙧 𝙎𝙩𝙧𝙤𝙠𝙚

𝘼𝙣𝙩𝙞𝙘𝙤𝙖𝙜𝙪𝙡𝙖𝙩𝙞𝙤𝙣 𝘼𝙛𝙩𝙚𝙧 𝙎𝙩𝙧𝙤𝙠𝙚 in Patient with AF and acute IS/TIA European Heart Association Guideline recommends: • 1 days after TIA • 3 days after mild stroke • 6 days after moderate stroke • 12 days after severe stroke Early anticoagulation can decrease a risk of recurrent stroke and embolic events but may increase a risk of secondary hemorrhagic transformation of brain infarcts. The 1-3-6-12-day rule is a known consensus with graded increase in delay of anticoagulation between 1 and 12 days after onset of ischemic stroke or transient ischemic attack(TIA), according to neurological severity based on European expert opinions. However, this rule might be somewhat later than currently used in a real-world practical setting.

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