RESPECT

Closure of patent foramen ovale versus medical therapy after cryptogenic stroke - The New England Journal of Medicine - 2013

Brief Summary:

Among patients with cryptogenic ischemic stroke, PFO closure does not reduce nonfatal ischemic stroke, stroke mortality, and early all-cause mortality when compared to medical therapy alone.

Reference: http://www.ncbi.nlm.nih.gov/pubmed/23514286