PROTECT AF

Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial – Lancet - 2009

Brief Summary:

Among patients with non-valvular atrial fibrillation, percutaneous left atrial appendage closure with the WATCHMAN device (without continued anticoagulation) is non-inferior to warfarin for the prevention of vascular events.

Reference: http://www.ncbi.nlm.nih.gov/pubmed/19683639

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