CASTLE-AF

Catheter Ablation for Atrial Fibrillation with Heart Failure - The New England Journal of Medicine - 2018

Brief Summary:

In patients with AF and symptomatic (NYHA II-IV) systolic heart failure (LVEF ≤ 35%), catheter ablation is associated with a 16.1% absolute reduction in death or hospitalization for heart failure when compared to medical therapy (rate or rhythm control). This difference was driven both by a 11.6% absolute reduction in death and a 15.2% absolute reduction in hospitalization for heart failure. Catheter ablation was also associated with greater improvement in LVEF and long-term maintenance of sinus rhythm.

Reference: http://www.ncbi.nlm.nih.gov/pubmed/29385358