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The effect of spironolactone on morbidity and mortality in patients with severe heart failure - New England Journal of Medicine - 1999

Brief Summary:

In patients with HFrEF (EF<35%) and NYHA III-IV symptoms, spironolactone led to a 30% reduction in all-cause mortality.

Reference: http://www.ncbi.nlm.nih.gov/pubmed/10471456

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