GUSTO

An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction - The New England Journal of Medicine - 1993

Brief Summary:

Among patients with ACS, rapidly administered tPA in addition to heparin and ASA reduces all-cause mortality at 30 days when compared ASA and heparin with either streptokinase or slowly-administered tPA and streptokinase.

Reference:
http://www.ncbi.nlm.nih.gov/pubmed/8204123