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Canagliflozin and cardiovascular and renal events in type 2 diabetes - The New England Journal of Medicine - 2017

Brief Summary:

Among patients with T2DM at high risk for CV events, canagliflozin had a lower risk of cardiovascular events and reduced the rate of renal decline and heart failure hospitalization compared to those who received placebo but a greater risk of amputation.

Reference: http://www.ncbi.nlm.nih.gov/pubmed/28605608

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