Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients - The New England Journal of Medicine - 2019

Brief Summary:

In patients with end-stage heart or lung disease requiring transplantation who are HCV negative, transplantation of HCV positive organs followed by immediate viral suppression with sofosbuvir/velpatasvir is feasible. At 6 months, all of 35 individuals (28 lung and 7 heart) transplanted had intact allograft function and undetectable HCV viral loads. In limited post-hoc analyses, overall transplant outcomes were similar to those observed with HCV- organs.