COGENT

Clopidogrel with or without omeprazole in coronary artery disease - The New England Journal of Medicine - 2010

Brief Summary:

Among patients with CAD requiring aspirin and clopidogrel, there was no significantly increased risk in CV events when omeprazole was added. However, there was a significant reduction in GI events, particularly an 87% reduction in overt upper GI bleed.

Reference: http://www.ncbi.nlm.nih.gov/pubmed/20925534