Ablation vs. Amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device - Circulation - 2016

Brief Summary:

In patients with symptomatic (NYHA II-III) heart failure with reduced ejection fraction (HFrEF, LVEF ≤40%) and persistent atrial fibrillation (AF) chosen for a rhythm control strategy, AF ablation was associated with a 36% absolute increase in AF-free survival at 24 months. There was also a 26% absolute reduction in unplanned hospitalizations and a 10% absolute reduction in overall mortality with AF ablation.

Reference: http://www.ncbi.nlm.nih.gov/pubmed/27029350